Dermaroller Research

This is a compiled list of resources that explains about product ingredients, dermaroller research, herbal research and vitamin research. This will explain why White Lotus derives it's information from

Derma Roller Research

1. Henry et al. demonstrated that microneedles of 150m/m length resulted in a 10,000 increase in absorption of calcein by the skin after the microneedles were removed. Henry S, McAllister DV, Allen MG, Prausnitz MR. Microfabricated microneedles: a novel approach to transdermal drug delivery. J Pharm Sci. 1998 Aug;87(8):922-5

 2. Kaushik et al (28) carried out a small trial to determine if microneedles are perceived as painless by human subjects. Microneedle arrays of 150�m length, were inserted into the skin of 12 subjects and compared to pressing a flat surface against the skin (negative control) and inserting a 26-gauge hypodermic needle into the skin surface (positive control). Subjects were unable to distinguish between the painless sensation of the flat surface and that caused by microneedles. Kaushik S, Hord AH, Denson DD, McAllister DV, Smitra S, Allen MG, Prausnitz MR. Lack of pain associated with microfabricatedmicroneedles. Anesth Analg. 2001 Feb;92(2):502-4.

 3. Fernandes D. demonstrated that microneedling can induce up to a 1,000% increase in collagen after a single treatment. Fernandes D. Minimally invasive percutaneous collagen induction. Oral Maxillofac Surg Clin North Am 2006;17:51-63.

4. Camirand, A. & Doucet, J. Demonstrated in case studies on a large number of patients that skin needling improves achromic, hypertrophic and unsightly scars in a simple safe and consistently effective way. Camirand, A. & Doucet, J. Needle Dermabrasion. Aesth. Plast. Surg. 21: 48-51, 1997.

5. Derma roller better than IPL for Scar treatments

Kim SE, Lee JH, Kwon HB, Ahn BJ, Lee AY.Greater collagen deposition with the microneedle therapy system than with intense pulsed light.Department of Dermatology, Graduate School of Medicine Medical Science Research Center, Dongguk University, Seoul, Gyeonggi-do, South Korea Reborn Dermatology Clinic, Seoul, South Korea.Dermatol Surg. 2011 Mar;37(3):336-41. doi: 10.1111/j.1524-4725.2011.01882.x. Epub 2011 Feb 22.

6.Aust MC, Knobloch K, Reimers K, Redeker J, Ipaktchi R, Altintas MA, Gohritz A, Schwaiger N, Vogt PM.Percutaneous collagen induction therapy: an alternative treatment for burn scars.Department for Plastic, Hand and Reconstructive Surgery, Hannover Medical School, Carl-Neubergstr. 1, 30625 Hannover, Germany. aust_matthias@gmx.deBurns. 2010 Sep;36(6):836-43. Epub 2010 Jan 13.

7.Percutaneous Collagen Induction Therapy: An Alternative Treatment for Scars, Wrinkles, and Skin Laxity
Aust, Matthias C. M.D.; Fernandes, Des M.D.; Kolokythas, Perikles M.D.; Kaplan, Hilton M. M.D.; Vogt, Peter M. M.DPlastic & Reconstructive Surgery:April 2008 - Volume 121 - Issue 4 - pp 1421-1429
doi: 10.1097/01.prs.0000304612.72899.02

Showed an increase in collagen and elastin deposits at 6 months and 40 percent thickening of stato spinosum at 1 year after1-4 treatments  for wrinkles lax skin, scarring stretch marks.

8.Aust MC, Vogt PM, Knobloch K
Percutaneous collagen induction therapy as a therapeutic option for striae distensae
Plast Reconstr Surg. 2010 Oct;126(4):219e-220e

9.Percutaneous Collagen Induction Therapy for Hand Rejuvenation
Matthias Aust, Karsten Knobloch, Andreas Gohritz, Peter M Vogt, Desmond Fernandes
Plastic, Hand, and Reconstructive Surgery; Hannover Medical School; Hannover, Germany (Aust, Knobloch, Gohritz, Vogt)
Department of Plastic and Reconstructive Surgery; Grooteschuur Hospital; Renaissance Body Science Institute; Cape Town, South Africa (Fernandes).

10.Percutaneous collagen induction-Regeneration in place of cicatrisation?
M C Aust, K Reimers, H M Kaplan, F Stahl, C Repenning, T Scheper, S Jahn, N Schwaiger, R Ipaktchi, J Redeker, M A Altintas, P M Vogt
Department for Plastic, Hand and Reconstructive Surgery, Medizinische Hochschule Hannover, Hannover, Germany.
Journal of plastic, reconstructive & aesthetic surgery : JPRAS. 04/2010; DOI: 10.1016/j.bjps.2010.03.038

11.Percutaneous collagen induction: An alternative to laser resurfacing
Des FernandesDes Fernandes, MD, Cape Town, South Africa, is a plastic surgeon.
Aesthetic surgery journal / the American Society for Aesthetic Plastic surgery. 06/2002; 22(3):307-9. DOI: 10.1067/maj.2002.126195

12.Combating photoaging with percutaneous collagen induction
Desmond Fernandes, Massimo Signorini
The Renaissance Surgical Clinic and Department of Plastic Reconstructive Surgery, University of Cape Town,Cape Town 8001, South Africa.
Clinics in dermatology. 26(2):192-9. DOI: 10.1016/j.clindermatol.2007.09.006

13.Minimally invasive percutaneous collagen induction
Desmond FernandesThe Shirnel Clinic and Department of Plastic Reconstructive Surgery, University of Cape TownOral and maxillofacial surgery clinics of North America. 03/2005; 17(1):51-63. DOI: 10.1016/j.coms.2004.09.004

Percutaneous Collagen Induction: Minimally Invasive Skin Rejuvenation without Risk of Hyperpigmentation-Fact or Fiction?Aust, Mathias C. M.D.; Reimers, Kerstin Ph.D.; Repenning, Claudia Ph.D.; Stahl, Frank Ph.D.; Jahn,Sabrina B.A.; Guggenheim, Merlin M.D.; Schwaiger, Nina M.D.; Gohritz, Andreas M.D.; Vogt, Peter M. M.D.

J Drug Target. 2010 Jan;18(1):15-20. Hair Regrowth Trial
Effect of applying modes of the polymer microneedle-roller on the permeation of L-ascorbic acid in rats.
You SK, Noh YW, Park HH, Han M, Lee SS, Shin SC, Cho CW.
College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon

Vitamin E Research-

All the following scientific trials found that Synthetic Vitamin E behaves entirely different to Natural Vitamin E. Vitamin E is prized for it's antioxidant properties and used extensively on the skin and internally.
Additionally the trials found that Natural Vitamin E to be at least twice as effective and additionally has been shown to have specific health benefits. So dont waste your money buying synthetic Vitamin E.

  1. Packer, L., Vitamin E is Nature’s Master Antioxidant, Science & Medicine, 1(1);54-63, 1994.
  2. Vitamin E Fact Book, VERIS (Vitamin E Research and Information Service), LaGrange IL, 1994.
  3. Callem, J., Smith, M.D., All About Vitamin E, Avery, NY, 1999.
  4. A Comparison of Natural and Synthetic Vitamin E, 1999
  5. Jiang, Q., Christen, S., Shigenaga, M.K., Ames, B.N., Gamma-Tocopherol, The Major Form of Vitamin E in the US Diet, Am. J. Clin. Nutr. 74:714-722, 2001.

Green Tea Research

LED Light And Green Tea Cream To Smooth Facial Wrinkles
Facial Rejuvenation in the Triangle of ROS
Andrei P. Sommer and Dan Zhu
Institute of Micro and Nanomaterials, University of Ulm, 89081 Ulm, Germany
Cryst. Growth Des., 2009, 9 (10), pp 4250–4254

The effects of tea extracts on proinflammatory signaling
Frank Pajonk1 , Anja Riedisser2 , Michael Henke2 , William H McBride1  and Bernd Fiebich2
1  Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1714,USA
2  Department of Radiation Oncology, University Hospital of Freiburg, Germany
3  Department of Psychiatry, University Hospital of Freiburg, Germany
BMC Medicine 2006, 4:28doi:10.1186/1741-7015-4-28
Published: 1 December 2006

Thring TS, Hili P, Naughton DP.Anti-collagenase, anti-elastase and anti-oxidant activities of extracts from 21 plants. BMC Complement Altern Med. 2009 Aug 4;9:27.School of Life Sciences, Kingston University, London, KT1 2EE, UK.

Antioxidant activity and bioactive compounds of tea seed(Camellia oleifera Abel.) oil.Lee CP, Yen GC.J Agric Food Chem. 2006 Feb 8;54(3):779-84.

Cutaneous photoprotection from ultraviolet injury by green tea polyphenols.
Elmets CA, Singh D, Tubesing K, Matsui M, Katiyar S, Mukhtar H.
Department of Dermatology, Case Western Reserve, Cleveland, Ohio, USA.

Wound Repair Regen. 2010 Jan-Feb;18(1):80-8. Epub 2009 Dec 11.
The effect of epigallocatechin-3-gallate, a constituent of green tea, on transforming growth factor-beta1-stimulated wound contraction.
Klass BR, Branford OA, Grobbelaar AO, Rolfe KJ.
SourceThe RAFT Institute, Mount Vernon Hospital, Northwood, Middlesex, United Kingdom.

Green tea polyphenolic antioxidants and skin photoprotection (Review).Katiyar SK, Elmets CA.Department of Dermatology, School of Medicine, University of Alabama at Birmingham, VH 501B, Birmingham, AL 35294, USA.

Elsaie, M.L., Abdelhamid, M.F., Elsaaiee, L.T., Emam, H.M. J Drugs Dermatol. 8(4): The efficacy of topical 2% green tea lotion in mild-to-moderate acne vulgaris. PubMed: U.S. National Library of Medicine and the National Institutes of Health. [Online] April 2009. [Cited: 29 December 2010.]  .

Mahmood, T., Akhtar, N., Khan, B.A., Khan, H.M., Saeed, T. Bosn J Basic Med Sci. 10(3): Outcomes of 3% green tea emulsion on skin sebum production in male volunteers. PubMed: U.S. National Library of Medicine and the National Institutes of Health. August 2010. [Cited: 29 December 2010.]

Ginseng Research

Panax ginseng induces human Type I collagen synthesis through activation of Smad signaling. Lee J, Jung E, Lee J, Huh S, Kim J, Park M, So J, Ham Y, Jung K, Hyun CG, Kim YS, Park D.J Ethnopharmacol. 2007 Jan 3;109(1):29-34. Epub 2006 Jul 3.

Ginsenosides enhance the transduction of tat-superoxide dismutase into mammalian cells and skin. Kim DW, Eum WS, Jang SH, Yoon CS, Choi HS, Choi SH, Kim YH, Kim SY, Lee ES, Baek NI, Kwon HY, Choi JH, Choi YC, Kwon OS, Cho SW, Han K, Lee KS, Park J, Choi SY.Mol Cells. 2003 Dec 31;16(3):402-6. Retraction in: Mol Cells. 2010 Apr;29(4):433.

Red ginseng root extract mixed with Torilus fructus and Corni fructus improves facial wrinkles and increases type I procollagen synthesis in human skin: a randomized, double-blind, placebo-controlled study. Cho S, Won CH, Lee DH, Lee MJ, Lee S, So SH, Lee SK, Koo BS, Kim NM, Chung JH.J Med Food. 2009 Dec;12(6):1252-9.

Effects of Ginseng Rhizome and Ginsenoside Ro on Testosterone 5a-Reductase and Hair Re-growth in Testosterone-treated Mice.Murata K, Takeshita F, Samukawa K, Tani T, Matsuda H.
Phytother Res. 2011 May 2. doi: 10.1002/ptr.3511

Effects of topically applied Korean red ginseng and its genuine constituents on atopic dermatitis-like skin lesions in NC/Nga mice.Kim HS, Kim DH, Kim BK, Yoon SK, Kim MH, Lee JY, Kim HO, Park YM.
Int Immunopharmacol. 2011 Feb;11(2):280-5. Epub 2010 Nov 27.

Korean red ginseng extract ameliorates skin lesions in NC/Nga mice: an atopic dermatitis model.
Lee JH, Cho SH.J Ethnopharmacol. 2011 Jan 27;133(2):810-7. Epub 2010 Nov 20.

Inhibition of pathogen adhesion to host cells by polysaccharides from Panax ginseng.
Lee JH, Shim JS, Chung MS, Lim ST, Kim KH.Biosci Biotechnol Biochem. 2009 Jan;73(1):209-12. Epub 2009 Jan 7.

For more information on dermaroller research please view dermaroller information pages.